https://www.davidwsanders.com/home daily 1.0 2025-07-29 https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/8dfb0715-f75c-4716-9566-b259f5e8aa88/25-07-08+Lab_Photo.jpg Sanders Lab of Molecular Networks - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.davidwsanders.com/projects daily 0.75 2025-07-28 https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609384386246-TIKM08L93YBOI8TDGMEK/BLIP_IMG.png Projects https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609377602186-XQMHZQVAVD7587XQBDIW/Syncytia_IMG.png Projects https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609377303984-0C9IGSCR9O87T6KR66E6/Network_Graph_IMG_PNG.png Projects https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/845fc180-cda5-4037-8294-18663b0f2c05/Fig2_Website.png Projects - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609379022153-2UTEKTY8QF1LYG57019Y/Strains_IMG.png Projects https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/470534ec-6ea8-4577-b3cc-704b7ac0406b/Speckle_Function_PNG.png Projects - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.davidwsanders.com/publications daily 0.75 2025-07-28 https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609371111968-4LQAN2ST6R3721YNI066/Westaway_IMG.jpg Publications - (7) The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition G Eskandari-Sedighi, N Daude, H Gapeshina, DW Sanders, R Kamali-Jamil, J Yang, B Shi, H Wille, B Ghetti, MI Diamond, C Janus, D Westaway Molecular Neurodegeneration (2017) [PDF] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609369299528-872UEPV6610WK5ZLECHJ/Riback_IMG.png Publications - (12) Composition dependent thermodynamics of intracellular phase separation JA Riback, L Zhu, MC Ferrolino, M Tolbert, DM Mitrea, DW Sanders, MT Wei, RW Kriwacki, CP Brangwynne Nature (2020) . [PDF] [Preview By Chiu Fan Lee] [Princeton Press Release] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/04cdf166-c5a2-408d-bbec-813fd7fe13ee/Chang_Okay_PNGG.png Publications - (18) Condensate interfaces can accelerate protein aggregation C-H Choi, DSW Lee, DW Sanders, CP Brangwynne Biophysical Journal (2023) [PDF] [Preview by Samrat Mukhopadhyay] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609367464326-TEO1YH3VMBGEKV0YS5K4/COVID_IMG_PNG.jpg Publications - (15) SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation DW Sanders*, CC Jumper*, PJ Ackerman*, D Bracha, A Donlic, H Kim, D Kenney, S Suzuki, T Tamura, I Castello-Serrano, AH Tavares, M Saeed, AS Holehouse, A Ploss, I Levental, F Douam, RF Padera, BD Levy, CP Brangwynne eLife (2021) Biorxiv (Pre-Print, Dec. 2020) [PDF-Main] [PDF-Supp] [HHMI News Story] [Presentation by Cliff] [THE Medical News Article] [Speak Russian? David doesn’t. But Grisha does] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609368710316-OXBNMRM71ZE7RS7EPXJE/Network_IMG_PNG.png Publications - (13) Competing protein-RNA interaction networks control multiphase intracellular organization DW Sanders, N Kedersha, DSW Lee, AR Strom, V Drake, JA Riback, D Bracha, JM Eeftens, A Iwanicki, A Wang, MT Wei, G Whitney, SM Lyons, P Anderson, WM Jacobs, P Ivanov, CP Brangwynne Cell (2020) [PDF-Main] [PDF-Supp] [Preview By Ashok Deniz] [Princeton Press Release] [Princeton Insights Coverage] [Fist-Bump from Mike Rosen in Science ] [Nature News-Building Out] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609371835081-G2H2RVRIHFZPG0NCRVD3/WU_IMG.png Publications - (5) Neuronal activity enhances tau propagation and tau pathology in vivo JW Wu, SA Hussaini, IM Bastille, GA Rodriguez, A Mrejeru, K Rilett, DW Sanders, C Cook, H Fu, RACM Boonen, M Herman, E Nahmani, S Emrani, YH Figueroa, MI Diamond, CL Clelland, S Wray, KE Duff Nature Neuroscience (2016) [PDF] [Columbia Press Release] [AlzForum Coverage] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609372139003-7GXJ9DZIFLXLO4B5KW1O/Review_IMG.jpg Publications - (4) REVIEW: Prions and protein assemblies that convey biological information in health and disease DW Sanders*, SK Kaufman*, BB Holmes*, MI Diamond Neuron (2016) [PDF] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1c655499-d6f5-411d-aef5-45a99d0fa825/Lee_Speckles_PNG.png Publications - (16) Size distributions of intracellular condensates reflect competition between coalescence and nucleation DSW Lee, CH Choi, DW Sanders, L Beckers, JA Riback, CP Brangwynne, NS Wingreen Nature Physics (2023) Biorxiv (Pre-print, Mar. 2022) [PDF] [Princeton Press Release] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609371253793-T5ATEQHWFM96TWDAV4T9/Rod_Microglia.png Publications - (6) Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo SK Kaufman*, DW Sanders*, TL Thomas, AJ Ruchinskas, J Vaquer-Alicea, AM Sharma, TM Miller, MI Diamond Neuron (2016) [PDF] [UT Southwestern Press Release] [AlzForum Coverage] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609370219278-I1IZKFCU97FYJTL3YXRR/Vale_Comment_IMG.png Publications - (10) COMMENTARY: Neurodegenerative disease: RNA repeats put a freeze on cells DW Sanders & CP Brangwynne Nature (2017) [PDF] See original paper from Jain &Vale! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/cc8250de-4d4d-4a26-98c5-fd547cf83010/Petrucelli_ImagePro.png Publications - (17) Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions J Park, Y Wu, W Shao, TF Gendron, SJF van der Spek, G Sultanakhmetov, A Basu, PC Otero, CJ Jones, K Jansen-West, LM Daughrity, S Phanse, G del Rosso, J Tong, M Castanedes-Casey, L Jiang, J Libera, B Oskarsson, DW Dickson, DW Sanders, CP Brangwynne, A Emili, B Wolozin, L Petrucelli, YJ Zhang Cell Reports (2023) [PDF] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609369841907-HE8NEUWKN5DGOUAUAR24/Shin_IMG.png Publications - (11) Liquid nuclear condensates mechanically sense and restructure the genome Y Shin, YC Chang, DSW Lee, J Berry, DW Sanders, P Ronceray, NS Wingreen, M Haataja, CP Brangwynne Cell (2018) [PDF] [Preview By Tuomas Knowles] [Nature Methods Overview] [Princeton Press Release] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609373079760-RUZDRJUA7NKUZNHUJM68/Prusiner_IMG.png Publications - (3) Propagation of prions causing synucleinopathies in cultured cells AL Woerman, J Stöhr, A Aoyagi, R Rampersaud, Z Krejciova, JC Watts, T Ohyama, S Patel, K Widjaja, A Oehler, DW Sanders, MI Diamond, WW Seeley, LT Middleton, SM Gentleman, DA Mordes, TC Südhof, K Giles, SB Prusiner PNAS (2015) [PDF] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609368016396-D3IZEPDOJA9LE2NB7J20/PB_SG_IMG.png Publications - (14) Nucleation landscape of biomolecular condensates SF Shimobayashi, P Ronceray, DW Sanders, MP Haataja, CP Brangwynne Nature (2021) [PDF] [Princeton Press Release] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609375338244-9FEF5Z4A5PPQS8435ZWZ/Strains_IMG.png Publications - (1) Distinct tau prion strains propagate in cells and mice and define different tauopathies. DW Sanders*, SK Kaufman*, SL DeVos, AM Sharma, H Mirbaha, A Li, SJ Barker, AC Foley, JR Thorpe, LC Serpell, TM Miller, LT Grinberg, WW Seeley, MI Diamond Neuron (2014) [PDF] [Preview by Brad Hyman] [WashU Press Release] [AlzForum Coverage of Paper] [AlzForum Coverage of Prelim Data] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/a04c9859-4116-4a7c-8c65-9fe10099a8db/Saha_Graphic_PNG.png Publications - (8) The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system I Saha, P Yuste-Checa, M Da Silva Padilha, Q Guo, R Körner, H Holthusen, VA Trinkaus, I Dudanova, R Fernández-Busnadiego, W Baumeister, DW Sanders, S Gautam, MI Diamond, FU Hartl, MS Hipp Nature Communications (2023) Biorxiv (Pre-print, Feb 2022) [PDF] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/3094181f-8312-42dc-89d4-0a4a17657003/DNAJC7_Structure_PNG.png Publications - (9) DNAJC7 specifically regulates tau seeding VA Perez, DW Sanders, A Mendoza-Oliva, BE Stopschinski, V Mullapudi, CL White, LA Joachimiak, MI Diamond eLife (2023) Biorxiv (Pre-print, Mar 2023) [PDF] https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1609373456261-1GXZYHM5XFJO5Y9X13G8/Mirbaha_IMG.png Publications - (2) Tau trimers are the minimal propagation unit spontaneously internalized to seed intracellular aggregation H Mirbaha, BB Holmes, DW Sanders, J Bieschke, MI Diamond Journal of Biological Chemistry (2015) [PDF] [Alzforum Coverage] https://www.davidwsanders.com/links daily 0.75 2025-07-28 https://www.davidwsanders.com/linkedin daily 0.75 2025-07-28 https://www.davidwsanders.com/videos daily 0.75 2025-07-28 https://www.davidwsanders.com/videos2 daily 0.75 2025-07-28 https://www.davidwsanders.com/videos3 daily 0.75 2025-07-28 https://www.davidwsanders.com/videos4 daily 0.75 2025-07-28 https://www.davidwsanders.com/people daily 0.75 2025-07-29 https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/ab878045-d242-4165-b5a6-a9fbedcec7b7/Ajay_Kota.png https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/103e1ef3-c486-425f-8f40-2cf6f8ea3d25/Shahmoradian_7099_HEADSHOT_CROP.jpg https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/0ac7a389-20d2-4511-a56a-c81cd7b7b594/DWSanders_Headshot_March24.jpg https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/3e072c62-cea3-4f45-8993-b83ebffae6c0/Vaibhav_JPG.jpg https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/b46c40f3-083f-4dd1-9dda-48ca85581562/Sydnie_Temp_Crop.png https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/71e75b43-61ae-4c82-86a7-1f992b61a01c/25-07-08+Lab_Photo.jpg https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/f4a0a9e5-419d-4ed6-a3bb-68502bc808ad/Haoxing_CATZ.png https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/bef13336-e39b-46e4-9f49-19d167373e7e/Harper_Averitt.jpg https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/5648cfe7-32e9-46c1-9b44-e5fffff31eb4/Shefali_NEW_Crop.jpg https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1593268530799-BTOA8PS1TLJ3YPRMHMTD/Sanders_FrontPaage.png https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/9a24ca52-703e-4c93-b432-4cd9510bfafc/Rupam_cropped.jpg https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/c9d4eebb-ab4e-491f-8b28-4efd39e0d9d6/Grisha.jpeg https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/55db9ed2-2d16-4816-861e-aa02871d6ffb/Jenny_Chu_Crop.png https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/1593268570998-OTC4L9965DZ3WN8ZROO4/Sanders_FrontPage.png https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/acb5ac11-9757-4111-af97-a605279d59b1/Yasmeen_Khan.jpg https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/b5131822-73ca-4718-9c3e-e6a4e84a135d/Vinni_K_Image.jpg https://www.davidwsanders.com/news daily 0.75 2025-10-08 https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/c1a8f903-8527-406c-8589-09bacd5f5356/25-07-11+Harper_Sydnie.jpg News June 9, 2025: We are delighted that undergraduate extraordinaire, Harper Averitt (left), has returned to the lab from her Baptist studies sabbatical. And we are excited to host UTSW Rising STAR and Youth Achiever, Sydnie Metrano (right). Harper will once again be coordinating with Rupam on our tau-polyserine epic; Sydnie, with Shefali on completing the lab’s first TDP story. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/28c42fc8-57cd-4f45-89d9-19ad50d7964d/25-07-02+Grisha_Wrestles_Child.jpg News July 2, 2025: After a humiliating loss to Victor, Grisha decided that his only hope to rehabilitate his reputation was to….wrestle a child. Heck of a job there, Grisha! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/41e047ba-c153-462f-a3a0-077285de71bc/25-03-26+Arm_Wrestle.jpg News March 27, 2025: First rule of Shahmorander Lab Fight Club. Talk about Shahmorander Lab Fight Club. Grisha vs. Victor. Grisha lost…clearly. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/f5000cd3-d73f-4b0b-86f7-74a9321284be/25-07-25+Youth_Achiver_Dinner.jpg News July 25, 2025: The Labs celebrated the hard work of our Youth Achievers by ending our week at UTSW’s local watering hole, Maple Landing. Beer and mocktails were consumed. Pizza was had. David and Sarah learned way too much about “kids these days” and their Socially Tiktak’ed Internets. Always great to host ambitious and curious local students in the lab! And learn a bit about how old we are! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/f4a0a9e5-419d-4ed6-a3bb-68502bc808ad/Haoxing_CATZ.png News - May 5, 2025: We welcome Haoxing Liang as a rotation student. He will be working with Grisha to cure the TDP…with cats, I assume? https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/61d74c04-cebb-4baf-ab1b-8a0f151f700c/25-05-15+Tri_Going_Away.jpg News May 15, 2025: We were sad to say goodbye to Sarah’s outstanding senior scientist, Tri Tran, who had been leading CLEM efforts in the Lab. We wish him the best of luck on the next stage of his scientific career! He may return one day for a classic Shahmorander twist! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/ebf906bf-eeb3-4974-a392-1f918d143cc2/David_Valerie.jpg News February 1, 2025: We joined Sarah Shahmoradian’s lab at Community to say goodbye to Valerie Perez, a postdoc with whom David has collaborated over the past 5-years. We wish her the best of luck in her new position at Thermo, where she will be freezing and milling anything they will allow her to! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/c01e5b9a-91c2-428e-aec4-bcde144ecaa9/25-07-04+Happy_4th_From_Grisha.jpeg News July 4, 2025: Happy America Day from all of us in the Shahmoranders group! No fingers were lost—at least on the highly prized pipetting hands of lab members. Fine, David did not check on their “useless” hands. Only need one hand to science! NOTE: with this “advertisement”, the Lab now meets the State Department’s new J1 requirements for employing “the internationals”. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/7653284e-dc98-4181-9ae1-bd307b4caf50/Ajay_Kota.png News - June 23, 2025: Another Youth Achiever crashed his way thru the UT Southwestern Summer Camp gauntlet to the Shahmoranders group: Ajay Kota, who joins us from beautiful Centennial High in the picturesque suburb of Frisco, TX! Ajay will be working with Victor and Olive on solving cryo-EM structures of cell-extracted tau and TDP-43 fibrils. He will also be defeating Grisha in bi-weekly arm wrestling beat-downs. His WWF idols include THE HULK HOGAN and Earthquake. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/2b48601b-2f46-4b33-8a1f-80e23833eaaa/25-07-19+Sydnie_Stars_1.jpg News July 25, 2025: Congratulations, Sydnie, for presenting an excellent poster at the Rising Stars Research Symposium! Sydnie shared her summer research on how optogenetic TDP assemblies inefficiently seed TDP fibril formation in cells. A very important contribution to the lab’s first manuscript, which we hope to share soon! Sydnie now leaves to South Dakota for commendable community outreach/service, but we hope she returns to continue her research in the near future! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/f4a0a9e5-419d-4ed6-a3bb-68502bc808ad/Haoxing_CATZ.png News - July 7, 2025: We are thrilled to announce that former rotation student, Haoxing Liang, has joined the lab as a PhD-seeking graduate student. Haoxing is currently setting up the lab’s first unbiased CRISPR screens! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/55db9ed2-2d16-4816-861e-aa02871d6ffb/Jenny_Chu_Crop.png News - June 30, 2025: Another week, another Shahmorander Youth Achiever unlocked! Welcome Jenny Chu to the lab! She joins us from the most competitive all-girls high school academy in the DFW area. Yeah, that’s right, talking about THE Hockaday School, yo! Jenny will be maximizing the potential of our labs’ computational image analysis pipelines. Her hobbies include writing poetry and outsmarting mean girls! We hate mean girls in the Shahmorander Group! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/0481f814-900b-43ad-ac5d-e09b2db21ee4/25-04-08+JLS_Dinner.png News - April 8, 2025: It was an honor to meet a hero of the Lab, Jennifer Lippincott-Schwartz, and learn about her latest stunning research on axonal transport. Thank you to Sarah for hosting and for providing an amazing opportunity to learn from one of the great! JLS is a true science rock God! David thanks her specifically for the encouraging words on how to mend fences with his idol who will not be named. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/550f87b4-2f17-49a9-9a5c-22329b59afd6/25-04-04+Welch_Celeb.png News - April 4, 2025: The Shamoranders celebrated David’s first “notice of award” at Social Pie—apparently, we invaded a private gathering but whatever! We are funded, ya jabronis, so back off! We are beyond grateful for three-years of funding from the Welch Foundation to support our efforts to understand how polyserine phosphorylation regulates RNA homeostasis. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/9105a7bb-0bf1-4d14-b0c1-7329a6b93f19/25-03-26+Dinner_with_Steven.JPEG News March 26, 2025: We were delighted to host friend of the Lab, Steven Boeynaems, from Baylor College of Medicine! He gave an excellent talk on how cationic peptides may trigger innate immunity signaling in neurodegenerative diseases! Always a delight to talk crazy ideas with Steven over a drink or two (or more)…with OMAKASE (!!!), clearly :) https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/b65b3a47-adb2-4d2f-9c2b-a750c7126851/25-05-13+PRC_Reception.png News May 13, 2025: Thank you to the President’s Research Council at UT Southwestern for funding our research on neuromuscular diseases! It was a pleasure for David to meet so many enthusiastic local backers of UTSW’s research mission….and was certainly humbling to receive so much attention—nice action shot of David with our favorite Dean, Andy Lee! And Marc, sure, sure. Marc’s okay too. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/2fecfd4b-dbe2-43b5-a678-7c3d1eee0000/25-07-19+Good_News_Lunch2.png News Oh….and the lab celebrated David’s very big, but embargoed, funding news at Jose over lunch. More to be shared shortly? https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/0d432241-9201-48c0-9140-b185294f1cd9/25-07-28+Celestial_Disentanglement.jpg News July 26, 2025: Thank you to Celestial Beerworks for brewing a tau-inspired IPA to raise awareness and $$$ for Alzheimer’s research at UT Southwestern. Fellow CAND PI, Lukasz Joachimiak, gets credit for the idea and execution. Hopefully, all in the Dallas area will help us drink our way to a cure! Your liver might not thank you, but our Center will! Livers are overrated if the taxpayer invests in NIH liver cures! https://www.davidwsanders.com/news-2 daily 0.75 2025-07-28 https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/529efd73-7e26-49ac-8efc-ad78e41a4681/Screenshot+2024-10-12+at+5.11.21%E2%80%AFPM.jpg News (Page 2) - October 4, 2024: Genentech, inventor of proteins, received the David Sanders seminar experience. A new lab enemy was made: that damn biotech-bro security robot. Never…ever….trust….robots! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/9a24ca52-703e-4c93-b432-4cd9510bfafc/Rupam_cropped.jpg News (Page 2) April 3, 2024: Today, we welcome our latest postdoctoral fellow, Rupam Ghosh, who abandoned the cash-laden fields of the consulting world to return to the academic fold. Rupam received a PhD from UT Southwestern, so is well versed in our unbreakable bureaucracy! Texas may love freedom, but not when it comes to paperwork! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/135da5c8-fb34-49ec-9fb1-38d287c9eca0/Vaibhav_JPG.jpg News (Page 2) - January 2, 2024: The Sanders Lab welcomes its first rotation student, Vaibhav Bommareddy, who journeys far from the mystical land of the medical scientist training program (MSTP) at UT Southwestern. He embraces the challenge of tackling both bench work and a daunting regimen of med school classes simultaneously. Pray for Vaibhav! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/3dd8af32-d5cb-441c-b73c-a47b547369aa/Yasmeen_Khan.jpg News (Page 2) - March 8, 2024: We are equally excited to share that the lab’s second postdoctoral fellow, Yasmeen Khan, has arrived! David enjoyed giving her a tour of the lab space today. She will officially start on Monday, planning to lead work on RNA homeostasis in the cytoplasm. Narrator: how did that transition to lysosome homeostasis? https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/75544f8a-823a-4f4f-9d18-699a83bf78a8/New_PI_Happy_Hour.jpg News (Page 2) February 7, 2024: David enjoyed attending the first UT Southwestern New PI Happy Hour! It was wonderful to meet so many excellent new colleagues. Thank you to Ashley Solmonson and Frankie Heyward for organizing! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/6dd9146b-46ba-43a9-974a-a98e88aab7cf/David_Mel.jpg News (Page 2) - July 14, 2023: David is excited to announce that the Sanders Lab will launch in November 2023 at UT Southwestern (primary appointment: Center for Alzheimer’s and Neurodegenerative Diseases; secondary appointments: Molecular Biology and the O’Donnell Brain Institute). We will pursue curiosity-driven science related to RNA-protein assemblies and diseases of aging! Please reach out if your favorite papers start with a mistake, following a serendipitous observation into the unknown. We will be hiring fearless iconoclasts at all levels! Special thanks to David’s partner, Mel (pictured), who is uprooting her life in New Jersey to join him in Dallas, Texas! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/6f7fbc72-7361-4887-bdda-6d1379af9c84/Michael.jpg News (Page 2) December 1, 2023: We are excited to welcome our first research scientist, Michael Jimenez, to the lab! Michael did his undergraduate studies at Texas A&M and hopes to learn everything he can about molecular biology. David can’t wait to teach this electrical engineer a bit about the messiness of cell biology. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/b41231ff-3889-4895-8a32-c18882f49893/Alex_speaking_2.jpg News (Page 2) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/cc75d05a-cbf8-44b0-a07c-5cce3fa107c4/Mantids_galore.jpeg News (Page 2) - March 31, 2024: Getting bigger! First molt soon! Still have 80+ survivors at Day 10. But guessing the crowded enclosure will cause mantids to climb over those molting and lead to rampant failed instar progressions. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/e2c28710-c167-4891-9ae5-4b9a47d011dd/Arrival_3.jpg News (Page 2) - November 1, 2023: The Sanders lab officially opens in the Center for Alzheimer’s and Neurodegenerative Diseases at UT Southwestern! David conquers Taleo training modules at unprecedented rates using multiple browsers! An intimidating number of orders are placed. Pictures are had. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/e9c9e798-f713-4dff-b1ac-008fe8b37c1c/IMG_0548.jpg News (Page 2) - April 14, 2024: The lab took its first group outing to some weird reptile/bug convention thing. While most lab members (reasonably) posed with snakes, sloths, and other cool breathing beasts, David spent the afternoon looking for weird bugs and sickly frogs. He bought some. EDIT: They were all eaten by maggots. Circle of academia….I mean, life. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/37636fd2-727d-413a-ab56-b297dc720a79/IMG_4945.jpg News (Page 2) - April 5, 2024: First Sanders Lab meeting. The most exciting one: discussion of database organization. Very metal! Next on agenda? Cure the diseases. First up: all of them. All. Guessing…boron (?)…is the answer? Certainly boron. Not manganese, that’s for sure. Still on my element shit list. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/e70907c9-877c-4143-a9ed-92527056c5c6/NikonSora.jpeg News (Page 2) - January 25, 2024: Team Nikon installs the Sanders Lab’s first microscope, a CSU-W1 SoRa, ahead of schedule. The lab quickly crushes the diffraction limit using a classic cell line created by David in 2012 (DS9 tau aggregate HEK293 cells)! https://x.com/DavidWSanders2/status/1750928003796799582?s=20 https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/c97da8bc-e12b-40c1-87ab-1d3a4d05b1e7/IMG_0476.jpg News (Page 2) - April 2, 2024: Big day for the lab. Baby mantid’s first molt! They grow up so fast! …New PI priorities. Time spent writing grants to date: 1 hour. Time spent attending to lab pet (mantis colony): 50 hours. No regrets. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/c9d4eebb-ab4e-491f-8b28-4efd39e0d9d6/Grisha.jpeg News (Page 2) - March 4, 2024: We are excited to announce that the lab’s first postdoctoral fellow, Grigorii (Grisha) Sultanakhmetov, has officially started! He will be working on TDP aggregation and whatever else he gets excited about tomorrow. Welcome to the lab, Grisha! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/d533c3fe-6db2-4783-bbd5-11b55bc35a10/PXL_20240414_201241485.jpg News (Page 2) - May 31, 2024: The entire lab is THRILLED to learn that Vaibhav Bommareddy will be joining the lab for his MD/PhD studies. David is personally humbled that such a remarkable young scientist would join his (new/untested) group. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/78769472-c6d1-4be2-9e4a-86ce312da6e9/Boxes.jpg News (Page 2) November 7, 2023: First packages have arrived! And we inherited our first piece of barely functional lab equipment! This item, a centrifuge of uncertain place and time, requires a three-step process to open. Fail? It chides the user with a loud "incorrect answer" buzz. Further, the user must slam the lid for it to close. Clearly, David is in love with this weathered machine. For he is a weathered machine. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/35236525-f792-456c-9cf1-542f7b7042ab/IMG_20240408_134316.jpg News (Page 2) - April 8, 2024: The sky got black because some stupid moon thing got in the way of the sun. So. The lab took the day off and trusted the integrity of our future eyesights to free eclipse glasses that were manufactured by an unknown vendor in an unknown country. We’re near a hospital. Sure it’s fine. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/16eb8e6c-656f-4005-b5e2-252fed59a3bd/Flash_Talk_Slide.jpg News (Page 2) February 16, 2024: David enjoyed giving a flash talk to students who have been accepted into the graduate programs at UT Southwestern. He hopes that they find their visitation weekends as magical as he did when he was in their shoes! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/35215553-5ce1-42c5-98b1-86340e2abd96/IMG_4910.jpg News (Page 2) - March 21, 2024: The Sanders lab has hundreds of mantids. Be afraid. Be very afraid! Video for the fans: https://x.com/DavidWSanders2/status/1770927008123429165 https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/3b3e5ffa-f033-416b-abea-9971824639c4/Film_Crew_3.jpg News (Page 2) February 15, 2024: Our lab space has unexpectedly become a hot spot to shoot promo commercials for UT Southwestern. Have a passion for science AND want to add a credit to your IMDB profile? Join the Sanders Lab. Where stars are born! https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/8fe990cb-20f1-4530-9a82-0c0219c3e596/Arrival_1.jpeg News (Page 2) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e3f08380b0aed2f275d04bb/b3908fd4-561d-42e9-8862-0c8c1cefa298/Vaibhav_Rests.jpg News (Page 2) - January 27, 2024: Vaibhav DESTROYS his first MSTP module final exam and takes advantage of the sumptuous desks of the lab to take a much deserved nap. Way to go, Vaibhav!