WHEN GOOD BIOLOGY DOES BAD THINGS: The Sanders Lab at UT Southwestern seeks to understand how failures in RNA and protein homeostasis trigger diseases of aging, from ALS to Alzheimer’s disease and myopathies. Our fundamental cell biology research is performed in close collaboration with the structural biology lab of Sarah Shahmoradian . The Sanders Lab’s expertise in live-cell imaging and cell models of RNA/protein aggregation—and phase separation (of course)—is leveraged in conjunction with the Shahmoradian Lab’s expertise in cryo-EM/ET and cryo-CLEM. This ongoing collaborative framework enables a cross-disciplinary approach to challenging questions of neurodegenerative and neuromuscular disease pathogenesis.

The Shahmoranders—photographed in their natural habitat above—are actively recruiting at all levels. If you have an insatiable thirst for destroying dogma (without using tamoxifen or single-cell sequencing), please reach out to David and/or Sarah to discuss career opportunities and/or collaboration!

See Projects and Publications for details on current and past work!

FULL STOP. See Videos if you want to get straight to the good stuff.

REACH OUT! We are always looking for collaborators! Email David! Or send David a message on your preferred networking platform if you have something interesting to say. He might have something interesting to say in response. He might not.