Videos

Co-expression of speckle proteins with cool multi-phase demixing. We would tell you more, but we need to publish this and related findings at some point. :)

Co-expression of optogenetic speckle protein (red) and unrelated speckle protein (green) with neat multi-phase demixing. Funky nucleoli too!

Co-expression of optogenetic speckle protein (red, not shown), which leads to cool multi-phase demixing of a different speckle protein (green).

But what does this mean for tau?

Human HEK293 cells with tau aggregates (green; see Sanders et al., Neuron, 2014) and optogenetic speckle protein (red).

Over-expressed speckle protein forms large, hollow droplets in the nucleus. This re-entrant behavior is common with proteins of similar amino acid composition (i.e. basic-acidic dipeptides)